BDBM50319005 (R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide::CHEMBL571948::Y-39983

SMILES C[C@@H](N)c1ccc(cc1)C(=O)Nc1ccnc2[nH]ccc12

InChI Key InChIKey=JTVBXQAYBIJXRP-SNVBAGLBSA-N

Data  3 KI  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50319005   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataKi:  28nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataIC50:  3.60nMAssay Description:Inhibitory activity against FAAH in Wistar rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataIC50:  3.60nMAssay Description:Inhibitory activity against FAAH in Wistar rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataEC50:  150nMAssay Description:Inhibition of ROCK-2 in human GTM3 cells measured up to 2 days by cell impedance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataIC50:  58nMAssay Description:Inhibition of truncated ROCK-2 (unknown origin) after 60 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataIC50:  120nMAssay Description:Inhibition of truncated ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataEC50:  790nMAssay Description:Inhibition of ROCK1 in human GTM3 cells by impedance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed