BDBM50330259 CHEMBL1236391::N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide::N-[3-(methylsulfanyl)-1-phenyl-1H-indazol-6-yl]piperidine-4-carboxamide::US8822447, 6::US9771375, Example 6

SMILES CSc1nn(-c2ccccc2)c2cc(NC(=O)C3CCNCC3)ccc12

InChI Key InChIKey=DHDKYDLNUPJXFQ-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50330259   

TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50330259(CHEMBL1236391 | N-(3-(methylthio)-1-phenyl-1H-inda...)
Affinity DataIC50:  590nMT: 2°CAssay Description:An enzymatic assay was developed to measure KHK-mediated conversion of D-fructose to Fructose-1-P (F-1-P) using High Throughput Mass Spectroscopy (HT...More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50330259(CHEMBL1236391 | N-(3-(methylthio)-1-phenyl-1H-inda...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50330259(CHEMBL1236391 | N-(3-(methylthio)-1-phenyl-1H-inda...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50330259(CHEMBL1236391 | N-(3-(methylthio)-1-phenyl-1H-inda...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50330259(CHEMBL1236391 | N-(3-(methylthio)-1-phenyl-1H-inda...)
Affinity DataIC50:  590nMAssay Description:An enzymatic assay was developed to measure KHK-mediated conversion of D-fructose to Fructose-1-P (F-1-P) using High Throughput Mass Spectroscopy (HT...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50330259(CHEMBL1236391 | N-(3-(methylthio)-1-phenyl-1H-inda...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50330259(CHEMBL1236391 | N-(3-(methylthio)-1-phenyl-1H-inda...)
Affinity DataIC50:  8.13E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50330259(CHEMBL1236391 | N-(3-(methylthio)-1-phenyl-1H-inda...)
Affinity DataIC50:  330nMAssay Description:Inhibition of KHK-mediated conversion of D-fructose to fructose-1-phosphate after 60 mins by high throughput mass spectrometry analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50330259(CHEMBL1236391 | N-(3-(methylthio)-1-phenyl-1H-inda...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed