BDBM50333184 5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridine-3-carboxic acid::5-(aminomethyl)-6-isobutyl-2-methyl-4-p-tolylnicotinic acid::CHEMBL1614729::CHEMBL1614729 (14)

SMILES CC(C)Cc1nc(C)c(C(O)=O)c(-c2ccc(C)cc2)c1CN

InChI Key InChIKey=NOAXOYPKZRNSHN-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50333184   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
China Pharmaceutical University

LigandPNGBDBM50333184(5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-m...)
Affinity DataIC50:  18nMAssay Description:The HypoGen module in DS2.5 was employed to produce pharmaphores with the training set compounds.More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
China Pharmaceutical University

LigandPNGBDBM50333184(5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-m...)
Affinity DataIC50:  18nMAssay Description:Inhibition of DDP4 in human Caco2 cells after 60 mins by spectrophotometryMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
China Pharmaceutical University

LigandPNGBDBM50333184(5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-m...)
Affinity DataIC50:  18nMAssay Description:Inhibition of DPP4 in human Caco2 cells after 60 minsMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50333184(5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-m...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of FLAG-tagged human DPP8 expressed in 293-F cells pre-incubated for 20 mins before Gly-Pro-pNA substrate addition and measured after 90 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50333184(5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-m...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of FLAG-tagged human DPP8 expressed in human 293F cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50333184(5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-m...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of FLAG-tagged human DPP9 expressed in human 293F cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
China Pharmaceutical University

LigandPNGBDBM50333184(5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-m...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human DPP4 purified from Caco2 cells pre-incubated for 15 mins before Gly-Pro-pNA substrate addition and measured after 60 minsMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 2(Rattus norvegicus)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50333184(5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-m...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of rat kidney DPP2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed