BDBM50335237 3-(1H-indol-3-yl)-4-[2-(4-oxo-piperidin-1-yl)-5-trifluoromethyl-ylpyrimidin-4-yl]-pyrrole-2,5-dione::3-(1H-indol-3-yl)-4-[2-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrrole-2,5-dione::CHEMBL1235315

SMILES FC(F)(F)c1cnc(nc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCC(=O)CC1

InChI Key InChIKey=MYIILBMNTUDZDH-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50335237   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335237(3-(1H-indol-3-yl)-4-[2-(4-oxo-piperidin-1-yl)-5-tr...)
Affinity DataIC50:  253nMAssay Description:Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335237(3-(1H-indol-3-yl)-4-[2-(4-oxo-piperidin-1-yl)-5-tr...)
Affinity DataIC50:  4.33E+3nMAssay Description:Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335237(3-(1H-indol-3-yl)-4-[2-(4-oxo-piperidin-1-yl)-5-tr...)
Affinity DataIC50:  27nMAssay Description:Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335237(3-(1H-indol-3-yl)-4-[2-(4-oxo-piperidin-1-yl)-5-tr...)
Affinity DataIC50:  330nMAssay Description:Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed