BDBM50335609 3-((4-(6-bromo-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole::6-BROMO-7-{4-[(5-METHYLISOXAZOL-3-YL)METHYL]PIPERAZIN-1-YL}-2-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-IMIDAZO[4,5-B]PYRIDINE::CHEMBL1236904

SMILES CN1CCN(CC1)c1ccc(cc1)-c1nc2ncc(Br)c(N3CCN(Cc4cc(C)on4)CC3)c2[nH]1

InChI Key InChIKey=GFLQCBTXTRCREJ-UHFFFAOYSA-N

Data  3 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50335609   

TargetAurora kinase A(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50335609(3-((4-(6-bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50335609(3-((4-(6-bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50335609(3-((4-(6-bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human ERG by whole-cell voltage clampingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50335609(3-((4-(6-bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed