BDBM50341064 3-(1-(4-amino-6-ethyl-1,3,5-triazin-2-yl)-1H-benzo[d]imidazol-2-ylamino)phenol::CHEMBL1762783

SMILES CCc1nc(N)nc(n1)-n1c(Nc2cccc(O)c2)nc2ccccc12

InChI Key InChIKey=RWVLCUCUWPHFTQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341064   

LigandChemical structure of BindingDB Monomer ID 50341064BDBM50341064(3-(1-(4-amino-6-ethyl-1,3,5-triazin-2-yl)-1H-benzo...)
Affinity DataIC50: 340nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341064BDBM50341064(3-(1-(4-amino-6-ethyl-1,3,5-triazin-2-yl)-1H-benzo...)
Affinity DataIC50: 390nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341064BDBM50341064(3-(1-(4-amino-6-ethyl-1,3,5-triazin-2-yl)-1H-benzo...)
Affinity DataIC50: 410nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of AKT at S473More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341064BDBM50341064(3-(1-(4-amino-6-ethyl-1,3,5-triazin-2-yl)-1H-benzo...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of 4EBP1 at T37/46More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed