BDBM50341068 2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol-1-yl)-6-methoxy-1,3,5-triazin-2-ylamino)acetonitrile::CHEMBL1762787

SMILES COc1nc(NCC#N)nc(n1)-n1c(Nc2cccc(O)c2)nc2ccccc12

InChI Key InChIKey=KBAFRYQOOQHQKY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341068   

LigandChemical structure of BindingDB Monomer ID 50341068BDBM50341068(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 520nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341068BDBM50341068(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of AKT at S473More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341068BDBM50341068(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 2.15E+4nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of 4EBP1 at T37/46More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341068BDBM50341068(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed