BDBM50341069 2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-ylamino)acetonitrile::CHEMBL1615182::[(4-{2-[(3-hydroxyphenyl)amino]-1H-benzimidazol-1-yl}-1,3,5-triazin-2-yl)amino]acetonitrile

SMILES Oc1cccc(Nc2nc3ccccc3n2-c2ncnc(NCC#N)n2)c1

InChI Key InChIKey=FEBJYEFFVIDUNF-UHFFFAOYSA-N

Data  4 KI  13 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50341069   

LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataKi:  52nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kdelta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataKi:  120nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataKi:  190nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kbeta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataKi:  350nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kalpha expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50:  100nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of c-Raf at 1 uM relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of KDR at 1 uM relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of CK1delta at 1 uM relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of DCAMKL3 at 1 uM relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TGFR2 at 1 uM relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50:  97nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50:  93nMAssay Description:Inhibition of recombinant GST-tagged mTOR-mediated 4EBP1 phosphorylation after 90 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50:  240nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50:  380nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50:  320nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of 4EBP1 at T37/46More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341069(2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol...)
Affinity DataIC50:  700nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of AKT at S473More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed