BDBM50350908 CHEMBL520308

SMILES CN(CCO)S(=O)(=O)c1ccc(cc1)-c1ccnc2[nH]c(C)cc12

InChI Key InChIKey=FKJNWJPAAVSRNX-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50350908   

TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of Aurora B kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50:  15nMAssay Description:Inhibition of IKKbeta expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50:  794nMAssay Description:Inhibition of IKK2 in human A549 cells assessed as inhibition of TNFalpha-induced NFKB activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50:  39.8nMAssay Description:Inhibition of IKK2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: <2.51E+4nMAssay Description:Inhibition of GSK3-beta kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of human recombinant IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A-interacting protein(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50:  7.94E+3nMAssay Description:Inhibition of Aurora A kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human recombinant ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50:  40nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed