BDBM50363645 DEBROMOHYMENIALDISINE
SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]ccc12
InChI Key InChIKey=JYRJOQGKGMHTOO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50363645
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Chk1Checked by AuthorMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 183nMAssay Description:Antagonist activity in rat uterus by uterotonic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 183nMAssay Description:Inhibition of human Chk2 using STK1 as substrate after 10 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 824nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University Of Utah
Curated by ChEMBL
University Of Utah
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of Chk2Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 183nMAssay Description:Inhibition of CHK2 (unknown origin) using polypeptide substrate after 40 mins in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 725nMAssay Description:Inhibition of CHK1 (unknown origin) using polypeptide substrate after 40 mins in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileumMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University Of Utah
Curated by ChEMBL
University Of Utah
Curated by ChEMBL
Affinity DataIC50: 820nMAssay Description:Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cellsMore data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:Antagonist potency on BK-induced contraction of guinea pig ileum longitudinal smooth muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cellsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 720nMAssay Description:Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 725nMAssay Description:Antagonist activity against adrenergic alpha-1A receptor in rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractionMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Antagonist activity in phenoxybenzamine-treated rat by Pressor assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 725nMAssay Description:Inhibition of human CHK1 using STK1 as substrate after 10 mins by HTRF assayMore data for this Ligand-Target Pair