BDBM50366044 CHEMBL1956741::US8927730, 3d
SMILES Cc1cc(N)nc(C[C@H]2CNC[C@H]2OCCNCc2ccco2)c1
InChI Key InChIKey=JGPWHIBNRITPFL-WMLDXEAASA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50366044
Affinity DataKi: 400nM ΔG°: -9.07kcal/mole IC50: 3.40E+3nMpH: 7.4 T: 2°CAssay Description:The three NOS isoforms, rat nNOS, murine iNOS and bovine eNOS were recombinant enzymes overexpressed in E. coli and purified as reported in the liter...More data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Inhibition of recombinant rat nNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.60E+4nM ΔG°: -6.30kcal/molepH: 7.4 T: 2°CAssay Description:The three NOS isoforms, rat nNOS, murine iNOS and bovine eNOS were recombinant enzymes overexpressed in E. coli and purified as reported in the liter...More data for this Ligand-Target Pair
Affinity DataKi: 3.60E+4nMAssay Description:Inhibition of recombinant mouse iNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 6.60E+4nMAssay Description:Inhibition of recombinant bovine eNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 6.60E+4nM ΔG°: -5.93kcal/molepH: 7.4 T: 2°CAssay Description:The three NOS isoforms, rat nNOS, murine iNOS and bovine eNOS were recombinant enzymes overexpressed in E. coli and purified as reported in the liter...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of rat nNOS expressed in HEK293T cells preincubated for 30 mins prior A23187-induced activation measured after 6 hrs by Griess assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant rat nNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair