BDBM50394166 CHEMBL2158859

SMILES CNC(=O)Nc1ccc(cc1)-c1cc(ccn1)-c1ccnc(Nc2cccc(c2)S(=O)(=O)NC)n1

InChI Key InChIKey=NWQHTOFIQMYFRC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50394166   

TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394166(CHEMBL2158859)
Affinity DataIC50:  210nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase SMG1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394166(CHEMBL2158859)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394166(CHEMBL2158859)
Affinity DataIC50:  100nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50394166(CHEMBL2158859)
Affinity DataIC50:  80nMAssay Description:Inhibition of PI3Kalpha using diC8-tagged PIP2 as substrate after 30 to 60 mins by TAMRA-based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394166(CHEMBL2158859)
Affinity DataIC50:  15nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50394166(CHEMBL2158859)
Affinity DataIC50:  82nMAssay Description:Inhibition of PI3Kgamma using diC8-tagged PIP2 as substrate after 30 to 60 mins by TAMRA-based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed