BDBM50396073 CHEMBL1235110

SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)c1

InChI Key InChIKey=NZNTWOVDIXCHHS-LSDHHAIUSA-N

Data  10 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50396073   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  4nMAssay Description:SYK tyrosine phosphorylation activity is measured using the LANCE Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.). ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  16nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  3.98E+3nMAssay Description:Inhibition of human recombinant Flag-6His-Thr-tagged Aurora B assessed as phosphorylation of 5FAM-PKA-tide substrate after 150 mins by fuorescence po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataEC50:  2.50E+3nMAssay Description:Inhibition of SYK in human platelet-rich plasma assessed as reduction in convulxin-induced GPV1/FcRgamma-mediated platelet aggregationMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
TargetPlatelet glycoprotein VI(Homo sapiens (Human))
University Of Leeds

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  31nMAssay Description:Modulation of GP6 in human platelets assessed as reduction in convulxin-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells after 2 hrs by Cy3b-Dofetilide-based fluorescence polarisation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet glycoprotein VI(Homo sapiens (Human))
University Of Leeds

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  48nMAssay Description:Modulation of GP6 in human platelets assessed as reduction in convulxin-induced P-selectin expression preincubated for 20 mins followed by convulxin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet glycoprotein VI(Homo sapiens (Human))
University Of Leeds

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  570nMAssay Description:Modulation of GP6 in human platelets reduction in collagen-induced platelet aggregation preincubated for 20 mins followed by collagen stimulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  5nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in Anti-IgG-stimulated FcgammaR-mediated leukotriene LTC4 production by fluoresce...More data for this Ligand-Target Pair