BDBM50412120 CHEMBL425190::SB-714786

SMILES Cc1ccc2c(OCCN3CCN(Cc4cccc5cccnc45)CC3)cccc2n1

InChI Key InChIKey=RMCSKUADBRROSI-UHFFFAOYSA-N

Data  22 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50412120   

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  316nMAssay Description:Inhibition of [3H]5HT uptake at SERT in rat cortical synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  316nMAssay Description:Displacement of [3H]WAY-100635 from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  316nMAssay Description:Inhibition of [3H]5-HT binding to serotonin transporter in rat cortical synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  316nMAssay Description:Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  501nMAssay Description:Binding affinity for human 5-hydroxytryptamine 7 receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity for human dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity for human alpha-1B adrenergic receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  1.26E+3nMAssay Description:Binding affinity for human 5-hydroxytryptamine 2B receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity for human beta-2 adrenergic receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1F receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi: <2.51E+3nMAssay Description:Binding affinity for human 5-hydroxytryptamine 2A receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  3.16E+3nMAssay Description:Binding affinity for human 5-hydroxytryptamine 2C receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  3.16E+3nMAssay Description:Binding affinity for human dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi:  3.16E+3nMAssay Description:Binding affinity for human 5-hydroxytryptamine 5A receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi: <5.01E+3nMAssay Description:Binding affinity for human 5-hydroxytryptamine 4 receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity for human dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity for human 5-hydroxytryptamine 6 receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1E(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412120(CHEMBL425190 | SB-714786)
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1E receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed