BDBM50418613 CHEMBL1232887

SMILES Cc1ccc(cc1-c1ccc(cn1)C(=O)NCC1CC1)C(=O)NC1CC1

InChI Key InChIKey=WIXHEGLMUQGJCC-UHFFFAOYSA-N

Data  2 KI  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50418613   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50418613(CHEMBL1232887)
Affinity DataKi:  9nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50418613(CHEMBL1232887)
Affinity DataKi:  25.1nMAssay Description:Inhibition of GST-tagged p38alpha by fluorescence polarization methodMore data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418613(CHEMBL1232887)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP1A2 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418613(CHEMBL1232887)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2C19 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50418613(CHEMBL1232887)
Affinity DataIC50:  316nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418613(CHEMBL1232887)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418613(CHEMBL1232887)
Affinity DataIC50:  3.98E+4nMAssay Description:Inhibition of human CYP2C9 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50418613(CHEMBL1232887)
Affinity DataIC50:  316nMAssay Description:Inhibition of p38alpha-dependent TNFalpha production in human whole blood preincubated for 1 hr before LPS challenge by ELISAMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418613(CHEMBL1232887)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed