BDBM50420775 CHEMBL581146::TCMDC-125324

SMILES Oc1c(cc(Cl)c2cccnc12)C(Nc1ccccn1)c1ccco1

InChI Key InChIKey=SZEZEZHDZJZXEC-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50420775   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50420775(CHEMBL581146 | TCMDC-125324)
Affinity DataIC50:  800nMAssay Description:Inhibition of human 6x-His tagged wild type BRAF expressed in Sf9 cells by ELISA based kinase assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Eutropics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50420775(CHEMBL581146 | TCMDC-125324)
Affinity DataIC50:  400nMAssay Description:Inhibition of human GST-tagged Mcl1 expressed in Escherichia coli BL21 using FITC-AHA-MRPEIWIAQELRRIGDEFNA-[NH2] after 20 mins by fluorescence polari...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed