BDBM50428119 CHEMBL2331658::US8791131, 133

SMILES COc1ccc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](OCCO)CC2)c(=O)n4C)cn1

InChI Key InChIKey=FSVNGKNQJXMWJY-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50428119   

LigandChemical structure of BindingDB Monomer ID 50428119BDBM50428119(CHEMBL2331658 | US8791131, 133)
Affinity DataKi:  0.5nM ΔG°:  -12.7kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50428119BDBM50428119(CHEMBL2331658 | US8791131, 133)
Affinity DataKi:  4.70nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50428119BDBM50428119(CHEMBL2331658 | US8791131, 133)
Affinity DataKi:  4.71nM ΔG°:  -11.4kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent