BDBM50450625 CHEMBL4160522

SMILES ONC(=O)c1ccc(Cl)c(NC(=O)c2cccc3ccsc23)c1

InChI Key InChIKey=FRUVCGVXUWSDQY-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50450625   

TargetHistone deacetylase 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450625(CHEMBL4160522)
Affinity DataIC50:  53nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus infected Sf9 insect cells using Z(Ac)Lys-AMC as substrate by flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450625(CHEMBL4160522)
Affinity DataIC50:  2.14E+4nMAssay Description:Inhibition of C-terminal FLAG/His-tagged full length human HDAC1 expressed in baculovirus infected Sf9 insect cells using Z(Ac)Lys-AMC as substrate b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50450625(CHEMBL4160522)
Affinity DataIC50:  155nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluorome...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50450625(CHEMBL4160522)
Affinity DataIC50:  97nMAssay Description:Inhibition of Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB