BDBM50452100 CHEMBL4216497

SMILES COc1ccc(Cl)cc1C[C@@H]1CN\C(CN(CC(=O)Nc2cccc(c2)S(C)(=O)=O)C1=O)=N/N(C)C

InChI Key InChIKey=NWZUZBYLXNQLIF-QGZVFWFLSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50452100   

TargetKallikrein-7(Homo sapiens (Human))
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452100(CHEMBL4216497)
Affinity DataIC50:  820nMAssay Description:Inhibition of thermolysin activated recombinant human C-terminal 10-His tagged KLK7 preincubated for 10 mins followed by MOCAc-Arg-Pro-Lys-Pro-Val-Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetKallikrein-7(Homo sapiens (Human))
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452100(CHEMBL4216497)
Affinity DataIC50:  820nMAssay Description:Inhibition of recombinant human KLK7 using MOCAc-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate preincubated for 10 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTrypsin(Homo sapiens (Human))
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452100(CHEMBL4216497)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human trypsin preincubated for 10 mins followed by Boc-Gln-Ala-Arg-MCA peptide substrate addition measured after 30 mins by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetKallikrein-5(Homo sapiens (Human))
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452100(CHEMBL4216497)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged KLK5 preincubated for 10 mins followed by Boc-Val-Pro-Arg-MCA peptide substrate addition mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed