BDBM50453161 CHEMBL4204999

SMILES [H][C@@]12CC=CC[C@]1([H])C(=NN(C(C)C)C2=O)c1ccc(OC)c(c1)-c1ccc(cc1)C(=O)NCC(N)=O

InChI Key InChIKey=STNWAGAHKRPYDJ-LEWJYISDSA-N

Data  4 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50453161   

TargetPhosphodiesterase(Trypanosoma brucei)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50453161(CHEMBL4204999)
Affinity DataKi:  100nMAssay Description:Inhibition of full length Trypanosoma brucei PDEB1 expressed in Sf21 insect cells using cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPhosphodiesterase(Trypanosoma brucei)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50453161(CHEMBL4204999)
Affinity DataKi:  100nMAssay Description:Inhibition of Trypanosoma brucei PDEB1 catalytic domain (565 to 918 residues) expressed in Escherichia coli BL21 incubated for 20 mins using cAMP as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50453161(CHEMBL4204999)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of human PDE4B catalytic domain incubated for 20 mins using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based luminometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50453161(CHEMBL4204999)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of full length recombinant human PDE4B1 expressed in Sf21 insect cells using cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed