BDBM50457827 CHEMBL4203759

SMILES CC(C)(O)COc1ccc(C(N)=O)c(O[C@H]2CCN(C[C@H]2F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1

InChI Key InChIKey=AUTGNDRENPBZKA-UXHICEINSA-N

Data  4 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50457827   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457827(CHEMBL4203759)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to un phosphorylated C-terminal His6/N-terminal BAP-tagged TrkA (441 to 796 residues) (unknown origin) by SPR assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457827(CHEMBL4203759)
Affinity DataIC50:  7.70E+3nMAssay Description:Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457827(CHEMBL4203759)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457827(CHEMBL4203759)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457827(CHEMBL4203759)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to un phosphorylated C-terminal His6/N-terminal BAP-tagged TrkA (441 to 796 residues) (unknown origin) assessed as dissociation rate...More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457827(CHEMBL4203759)
Affinity DataIC50:  3.90nMAssay Description:Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed