BDBM50459099 CHEMBL4202981
SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC(=O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc34)cc2Cl)cc1
InChI Key InChIKey=VQICVPORQPLTMV-IKVATAHOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50459099
Affinity DataEC50: 126nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: <2.51E+4nMAssay Description:Inhibition of mouse IBAT expressed in COS cells assessed as reduction in [3H]taurocholic acid uptakeMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: <5.01E+4nMAssay Description:Activation of human FXRMore data for this Ligand-Target Pair
Affinity DataEC50: 125nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMAssay Description:Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: <2.51E+4nMAssay Description:Inhibition of human IBAT expressed in COS cells assessed as reduction in [3H]taurocholic acid uptakeMore data for this Ligand-Target Pair