BDBM50460801 CHEMBL4086524::US11116757, No. Table11.10

SMILES FC(F)(F)c1cccc(NC(=O)NC2CCN(Cc3ccccc3)CC2)c1

InChI Key InChIKey=MXZRHPHRSQJCML-UHFFFAOYSA-N

Data  4 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50460801   

TargetDCN1-like protein 1(Homo sapiens)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50460801(CHEMBL4086524 | US11116757, No. Table11.10)
Affinity DataEC50:  4.20E+3nMAssay Description:Inhibition of human DCN1-mediated cullin neddylation assessed as reduction in transfer of fluorescein-5-maleimide-tagged NEDD8 from N-terminally acet...More data for this Ligand-Target Pair
TargetDCN1-like protein 1(Homo sapiens)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50460801(CHEMBL4086524 | US11116757, No. Table11.10)
Affinity DataIC50:  7.60E+3nMAssay Description:Binding affinity biotinylated human GST-tagged DCN1 assessed as inhibition of protein interaction with AlexaFluor 488-tagged and N-terminally acetyla...More data for this Ligand-Target Pair
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Homo sapiens)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50460801(CHEMBL4086524 | US11116757, No. Table11.10)
Affinity DataIC50:  5.50E+3nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Homo sapiens)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50460801(CHEMBL4086524 | US11116757, No. Table11.10)
Affinity DataIC50:  5.50E+3nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Homo sapiens)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50460801(CHEMBL4086524 | US11116757, No. Table11.10)
Affinity DataIC50:  8.75E+3nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair