BDBM50468187 CHEMBL4288634

SMILES COc1ccc(nc1)-c1c([nH]c2cccnc12)-c1ccnc(NC(C)=O)c1

InChI Key InChIKey=VRPRBQAJAQCSCW-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50468187   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL

LigandBDBM50468187(CHEMBL4288634)Copy SMILESCopy InChI

Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of wild type TGFbetaR2 (unknown origin) kinase domain after 1 hr by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL

LigandBDBM50468187(CHEMBL4288634)Copy SMILESCopy InChI

Affinity DataIC50:  6nMAssay Description:Inhibition of TGFbetaR1 T204D mutant (unknown origin) kinase domain after 1 hr by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI