BDBM50485026 CHEMBL2023498

SMILES CCCS(=O)(=O)Nc1ccc(F)c(c1F)-c1cc2cnc(NCCCO)nc2n(C)c1=O

InChI Key InChIKey=HCWAUGCXCGOSNN-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50485026   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50485026(CHEMBL2023498)
Affinity DataIC50:  41nMAssay Description:Inhibition of full-length B-Raf V600E mutant in human MALME-3M cells assessed as reduction in basal ERK1/2 phosphorylation incubated for 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50485026(CHEMBL2023498)
Affinity DataIC50:  7nMAssay Description:Inhibition of full-length B-Raf V600E mutant assessed as reduction in incorporation of radiolabeled phosphate from [gamma-33P]ATP into FSBA-modified ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB