BDBM50486055 CHEMBL2204507

SMILES COc1cccc(C(=O)NC2CC3CCC(C2)N3c2ccc(cn2)C(=O)NCc2ccccc2)c1C

InChI Key InChIKey=JXXRMCOYDPMQEY-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50486055   

TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486055(CHEMBL2204507)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of Hsp90 in human A549 cells assessed as Raf1 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50486055(CHEMBL2204507)
Affinity DataIC50:  479nMAssay Description:Inhibition of His6-tagged N-terminal human HSP90alpha expressed in Escherichia coli BL21 Lys cells preincubated for 10 mins followed by SA-APC and bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486055(CHEMBL2204507)
Affinity DataIC50:  479nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB