BDBM50491278 CHEMBL2381970

SMILES OC(=O)C1CCCCC1C(=O)N1CCc2ccccc2C1CN1C(=O)c2ccccc2C1=O

InChI Key InChIKey=LNENLABLFGGAFF-UHFFFAOYSA-N

Data  1 Kd  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50491278   

TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50491278(CHEMBL2381970)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of Keap1-Nrf2 interaction in human U2OS cells assessed as Nrf2 nuclear translocation by beta-lactamase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50491278(CHEMBL2381970)
Affinity DataKd:  7.00E+5nMAssay Description:Binding affinity to Keap1 kelch domain (unknown origin) by competitive SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50491278(CHEMBL2381970)
Affinity DataEC50: >1.00E+8nMAssay Description:Inhibition of Keap1-Nrf2 interaction in human HepG2 cells expressing ARE-bla assessed as activation of antioxidant response element by beta-lactamase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed