BDBM50501456 CHEMBL4088755

SMILES COc1ccc(Cn2cnc3sc4CC(CCc4c3c2=O)NCc2c(C)noc2C)c2ccccc12

InChI Key InChIKey=HBGRZTNWJBBJHU-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50501456   

TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501456(CHEMBL4088755)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged SIRT3 (101 to 399 residues) expressed in Escherichia coli using p53 derived (379 to 382 residue...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501456(CHEMBL4088755)
Affinity DataIC50:  580nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501456(CHEMBL4088755)
Affinity DataIC50:  1.29E+5nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SIRT1 (1 to 747 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed