BDBM50502541 Elafibranor::GFT-505::Gft505
SMILES CSc1ccc(cc1)C(=O)\C=C\c1cc(C)c(OC(C)(C)C(O)=O)c(C)c1
InChI Key InChIKey=AFLFKFHDSCQHOL-IZZDOVSWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50502541
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Affinity DataEC50: 2.12E+3nMAssay Description:Agonist activity at PPARgamma (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Affinity DataEC50: 175nMAssay Description:Agonist activity at PPARgamma (unknown origin) assessed as transcriptional activationMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Affinity DataEC50: 115nMAssay Description:Agonist activity at PPARbeta (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Terns Pharmaceuticals
Curated by ChEMBL
Terns Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Guangzhou Medical University
Curated by ChEMBL
Guangzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 3.96E+4nMAssay Description:Inhibition of NLRP3 in mouse J774A.1 cells infected with FLA-ST assessed as inhibition of LPS- induced IL-1beta production by ELISAMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Terns Pharmaceuticals
Curated by ChEMBL
Terns Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 375nMAssay Description:Agonist activity at human PPARalpha transfected in human HepG2 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Affinity DataEC50: 3.96E+3nMAssay Description:Agonist activity at human PPARgamma transfected in human HEK293 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Affinity DataEC50: 249nMAssay Description:Agonist activity at human PPARdelta transfected in human HEK293 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Terns Pharmaceuticals
Curated by ChEMBL
Terns Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 760nMAssay Description:Agonist activity at human Gal4 fused PPARalpha LBD expressed in COS-7 cells incubated for 24 hrs by firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Affinity DataEC50: 730nMAssay Description:Agonist activity at human Gal4 fused PPARdelta LBD expressed in COS-7 cells incubated for 24 hrs by firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Affinity DataEC50: 2.79E+3nMAssay Description:Agonist activity at human Gal4 fused PPARgamma LBD expressed in COS-7 cells incubated for 24 hrs by firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Terns Pharmaceuticals
Curated by ChEMBL
Terns Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 820nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Affinity DataEC50: 843nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Wuxi Apptec (Shanghai) Co.
Curated by ChEMBL
Affinity DataEC50: 1.84E+3nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Terns Pharmaceuticals
Curated by ChEMBL
Terns Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 45nMAssay Description:Agonist activity at PPARalpha (unknown origin) assessed as transcriptional activationMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Terns Pharmaceuticals
Curated by ChEMBL
Terns Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 225nMAssay Description:Agonist activity at PPARalpha (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assayMore data for this Ligand-Target Pair