BDBM50526266 CHEMBL4565193

SMILES Clc1cc(N[C@H]2CC[C@@H](CC2)NC(=O)CN2CCOCC2)c2ncc(-c3ccc4[nH]ncc4c3)n2n1

InChI Key InChIKey=ZXATZKPFQCMICU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50526266   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM50526266(CHEMBL4565193)
Affinity DataIC50: 27nMAssay Description:Inhibition of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) -dependent cleavage of FAM-labeled stem-loop RNA containing the XBP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM50526266(CHEMBL4565193)
Affinity DataIC50: 87nMAssay Description:Displacement for LanthaScreen tracer from dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) ATP binding site KEN domain after 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM50526266(CHEMBL4565193)
Affinity DataIC50: 240nMAssay Description:Inhibition of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) autophosphorylation at S724 after 25 mins in presence of ATP by dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM50526266(CHEMBL4565193)
Affinity DataIC50: 680nMAssay Description:Inhibition of thapsigargin-induced IRE1alpha (unknown origin) expressed in HEK293 cells assessed as reduction in IRE1alpha-dependent splicing of XBP1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM50526266(CHEMBL4565193)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of tunicamycin-induced IRE1alpha (unknown origin) expressed in HEK293 cells assessed as reduction in IRE1alpha-dependent splicing of XBP1u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM50526266(CHEMBL4565193)
Affinity DataIC50: 1.88E+3nMAssay Description:Inhibition of tunicamycin-induced GFP-fused IRE1alpha (unknown origin) oligomerization expressed in HEK293 cells assessed as reduction in fluorescent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed