BDBM50539921 CHEMBL4649802::US11142507, Compound MFH-2-25-1

SMILES CC(C)(C)c1cnc(CSc2nnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1

InChI Key InChIKey=ZGTBRXCHDKWPQT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50539921   

TargetCyclin-dependent kinase 9(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50539921(CHEMBL4649802 | US11142507, Compound MFH-2-25-1)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent

LigandPNGBDBM50539921(CHEMBL4649802 | US11142507, Compound MFH-2-25-1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full-length His-tagged CDK7/Cyclin H/MNAT1 expressed in baculovirus infection system using Cdk7/9tide as substrate me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-dependent kinase 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50539921(CHEMBL4649802 | US11142507, Compound MFH-2-25-1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged CDK2/cyclinA1 expressed in baculovirus infected Sf9 insect cells using FRET-labeled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50539921(CHEMBL4649802 | US11142507, Compound MFH-2-25-1)
Affinity DataIC50: 1.00E+4nMAssay Description:Jurkat cells were treated with DMSO or concentration of compound indicated. 6 hours after treatment, cells were washed and harvested by resuspending ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50539921(CHEMBL4649802 | US11142507, Compound MFH-2-25-1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full-length His-tagged CDK9/Cyclin T1 expressed in baculovirus infection system using Cdk7/9tide as substrate measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50539921(CHEMBL4649802 | US11142507, Compound MFH-2-25-1)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent