BDBM50598792 CHEMBL5188380

SMILES Nc1cc(ccc1CN1CCC[C@H](O[C@H](CO)c2cc(Cl)cc(Cl)c2)[C@@H]1c1ccccc1)C(O)=O

InChI Key InChIKey=WIHIMICVVOCQNM-NXCFDTQHSA-N

Data  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50598792   

TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50598792(CHEMBL5188380)
Affinity DataEC50:  1.68E+5nMAssay Description:Activation of basal state recombinant PKG1alpha (unknown origin) using Glass-tide peptide substrate incubated for 30 mins followed by ATP addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50598792(CHEMBL5188380)
Affinity DataEC50:  3.20E+3nMAssay Description:Activation of cGMP induced partially activated state recombinant human full length N-terminal His tagged PKG1beta expressed in Baculovirus infected S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50598792(CHEMBL5188380)
Affinity DataEC50:  3.33E+4nMAssay Description:Activation of PKG1alpha in human HEK293 cells stably expressing VASP assessed as VSAP phosphorylation at Ser 239 incubated for 45 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50598792(CHEMBL5188380)
Affinity DataEC50:  290nMAssay Description:Activation of cGMP induced partially activated state recombinant PKG1alpha (unknown origin) using Glass-tide peptide substrate incubated for 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB