BDBM513671 US11091495, Example 173::US11091495, Example 202::US11091495, Example 223::US11091495, Example 32::US11220509, Example 223::US11485738, Example 223

SMILES CN(C)Cc1ccc(c(C)c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N

InChI Key InChIKey=FLCIOLFIDGTRCI-UHFFFAOYSA-N

Data  19 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 513671   

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50:  300nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50:  300nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50:  300nMAssay Description:An aliquot of each serial dilution of test compound was added to deep 384 well plate using Acoustic Technology instrument (Echo 550, LabCyte) contain...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:An aliquot of each serial dilution of test compound was added to deep 384 well plate using Acoustic Technology instrument (Echo 550, LabCyte) contain...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:An aliquot of each serial dilution of test compound was added to deep 384 well plate using Acoustic Technology instrument (Echo 550, LabCyte) contain...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:An aliquot of each serial dilution of test compound was added to deep 384 well plate using Acoustic Technology instrument (Echo 550, LabCyte) contain...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50:  300nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Mirati Therapeutics

US Patent

LigandBDBM513671(US11091495, Example 173 | US11091495, Example 202 ...)Copy SMILESCopy InChI

Affinity DataIC50: <100nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI