BDBM538108 US11253516, Example 10

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCC(CC1)N1CCN(C)CC1

InChI Key InChIKey=MPISIZFSGAZROV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 538108   

TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 538108BDBM538108(US11253516, Example 10)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of EGFR Del19/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 538108BDBM538108(US11253516, Example 10)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human EGFR del19/T790M/C797S mutant using ATP-labelled peptide substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 538108BDBM538108(US11253516, Example 10)
Affinity DataIC50: 0.200nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 538108BDBM538108(US11253516, Example 10)
Affinity DataIC50: 0.700nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 538108BDBM538108(US11253516, Example 10)
Affinity DataIC50: 4nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 538108BDBM538108(US11253516, Example 10)
Affinity DataIC50: 430nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 538108BDBM538108(US11253516, Example 10)
Affinity DataIC50: 430nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 538108BDBM538108(US11253516, Example 10)
Affinity DataIC50: 430nMAssay Description:Inhibition of human wild type EGFR using ATP-labelled peptide substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed