BDBM599417 5-(4-amino-6- cyanopyrrolo[2,1- f][1,2,4]triazin-7-yl)-N- ((3R,4S)-4-fluoro-1-(3,3,3- trifluoro-2,2- dimethylpropanoyl)pyrrol- idin-3-yl)-2- methoxynicotinamide::US11618753, Example 560

SMILES COc1ncc(cc1C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C(C)(C)C(F)(F)F)-c1c(cc2c(N)ncnn12)C#N

InChI Key InChIKey=PSNBJACOQJKERT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 599417   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM599417(US11618753, Example 560 | 5-(4-amino-6- cyanopyrro...)
Affinity DataIC50: 1.40E+4nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2023
Entry Details
US Patent