BDBM6780 3-[1-(2,3-dihydroxypropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::bis-indolylmaleimide deriv. 8j

SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CC(O)CO)c3ccccc23)c2ccccc12

InChI Key InChIKey=UBUCTCIBRLMJKZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6780   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM6780(3-[1-(2,3-dihydroxypropyl)-1H-indol-3-yl]-4-(1-met...)
Affinity DataIC50:  2.14E+3nMpH: 7.0 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM6780(3-[1-(2,3-dihydroxypropyl)-1H-indol-3-yl]-4-(1-met...)
Affinity DataIC50:  1.61E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Eli Lilly

LigandPNGBDBM6780(3-[1-(2,3-dihydroxypropyl)-1H-indol-3-yl]-4-(1-met...)
Affinity DataIC50: >2.00E+4nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM6780(3-[1-(2,3-dihydroxypropyl)-1H-indol-3-yl]-4-(1-met...)
Affinity DataIC50:  1.61E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed