BindingDB BDBM78433 2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]propyl]-1-piperazinyl]ethanol;hydrochloride::2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;hydrochloride::2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazino]ethanol;hydrochloride::FLUPHENAZINE::FLUPHENAZINE HYDROCHLORIDE::MLS001076508::SMR000058411::cid_3372::cid

BDBM78433 2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]propyl]-1-piperazinyl]ethanol;hydrochloride::2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;hydrochloride::2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazino]ethanol;hydrochloride::FLUPHENAZINE::FLUPHENAZINE HYDROCHLORIDE::MLS001076508::SMR000058411::cid_3372::cid_6602611::med.21724, Compound 17

SMILES OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1

InChI Key InChIKey=PLDUPXSUYLZYBN-UHFFFAOYSA-N

Data 95 KI 21 IC50 3 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 78433

Mitochondrial import inner membrane translocase subunit TIM10(Saccharomyces cerevisiae S288c)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay

BDBM78433(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)

IC50: 3.13E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair

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Ubiquitin-conjugating enzyme E2 N(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay

BDBM78433(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)

IC50: 1.73E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair

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Bcl-2-related protein A1(Mus musculus (Mouse))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay

BDBM78433(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)

IC50: >2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair

PDB MMDB KEGG
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Ubiquitin-conjugating enzyme E2 N(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay

BDBM78433(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)

IC50: 1.75E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair

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Filter my 119 hits

Targets 42▿
- D(2) dopamine receptor 23
- D(1A) dopamine receptor 11
- 5-hydroxytryptamine receptor 2A 7
- D(3) dopamine receptor 6
- 5-hydroxytryptamine receptor 2C 6
- Histamine H1 receptor 5
- D(4) dopamine receptor 4
- 5-hydroxytryptamine receptor 6 4
- Alpha-2A adrenergic receptor 4
- Alpha-1A adrenergic receptor 3
- 5-hydroxytryptamine receptor 7 3
- ATP-dependent translocase ABCB1 3
- Alpha-2C adrenergic receptor 2
- Potassium channel subfamily K member 2 2
- Dopamine receptor D4 2
- Alpha-2B adrenergic receptor 2
- 5-hydroxytryptamine receptor 1A 2
- D(1B) dopamine receptor 2
- Muscarinic acetylcholine receptor M2 2
- Spike glycoprotein 2
- Bile salt export pump 2
- Ubiquitin-conjugating enzyme E2 N 2
- Pleiotropic ABC efflux transporter of multiple drugs 1
- Solute carrier family 22 member 1 1
- Sigma non-opioid intracellular receptor 1 1
- Histamine H3 receptor 1
- Replicase polyprotein 1ab 1
- Muscarinic acetylcholine receptor M3 1
- Adenylate cyclase type 1/Adenylate cyclase type 2/Adenylate cyclase type 3/Adenylate cyclase type 4/Adenylate cyclase type 5/Adenylate cyclase type 6/Adenylate cyclase type 8/Adenylyl cyclase 7 1
- ATP-binding cassette sub-family C member 3 1
- ATP-binding cassette sub-family C member 4 1
- ATP-binding cassette sub-family C member 2 1
- Bcl-2-related protein A1 1
- Orf1a protein 1
- Androgen receptor 1
- 5-hydroxytryptamine receptor 3A 1
- Mitochondrial import inner membrane translocase subunit TIM10 1
- NADPH oxidase 1 1
- 5-hydroxytryptamine receptor 1A/1B/1D/2C 1
- Sodium channel protein type 1/2/3 subunit alpha 1
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 1
- Trypanothione reductase 1
- ...
Publications 46▿
- Neuropsychopharmacology 28: 519-26 (2003) 12
- NIDA Res Monogr 178: 440-66 (1998) 7
- Ann N Y Acad Sci 537: 435-42 (1988) 7
- Mol Pharmacol 12: 800-12 (1976) 7
- Bioorg Med Chem Lett 19: 538-42 (2008) 6
- J Neuropsychiatry Clin Neurosci 8: 223-6 (1996) 5
- J Pharmacol Exp Ther 268: 1403-10 (1994) 5
- J Pharmacol Exp Ther 315: 1278-87 (2005) 5
- Eur J Pharmacol 103: 197-204 (1984) 5
- Med Res Rev (2020) 4
- Toxicol Sci 136: 216-41 (2013) 4
- Psychopharmacology (Berl) 120: 365-8 (1995) 3
- Biochem Biophys Res Commun 289: 580-5 (2001) 3
- Mol Psychiatry 3: 123-34 (1998) 3
- J Pharmacol Exp Ther 259: 323-9 (1991) 3
- Neuropsychopharmacology 16: 93 (1997) 3
- Synapse 25: 137-46 (1997) 2
- Nature 350: 610-4 (1991) 2
- Br J Pharmacol 130: 692-8 (2000) 2
- Eur J Pharmacol 146: 113-20 (1988) 2
- J Pharmacol Exp Ther 260: 1361-5 (1992) 2
- Life Sci 37: 1971-83 (1985) 2
- Nature 350: 614-9 (1991) 2
- J Pharmacol Exp Ther 295: 226-32 (2000) 1
- J Med Chem 41: 148-56 (1998) 1
- PubChem Bioassay (2011) 1
- Antimicrob Agents Chemother 53: 1516-27 (2009) 1
- Synapse 38: 438-49 (2000) 1
- Chem Biol Drug Des 88: 807-819 (2016) 1
- PubChem Bioassay (2011) 1
- PubChem Bioassay (2011) 1
- J Med Chem 63: 1937-1963 (2020) 1
- J Med Chem 59: 5149-57 (2016) 1
- J Med Chem 29: 1628-37 (1986) 1
- Drug Metab Dispos 40: 2332-41 (2012) 1
- Life Sci 35: 1885-93 (1984) 1
- J Med Chem 28: 381-8 (1985) 1
- J Pharmacol Exp Ther 264: 1002-11 (1993) 1
- PubChem Bioassay (2010) 1
- Proc Natl Acad Sci U S A 75: 6290-4 (1978) 1
- Proc Natl Acad Sci U S A 81: 4983-7 (1984) 1
- J Med Chem 51: 5932-42 (2008) 1
- J Neurochem 66: 47-56 (1996) 1
- Proc Natl Acad Sci U S A 104: 11927-32 (2007) 1
- PubChem Bioassay (2010) 1
- J Pharmacol Exp Ther 253: 214-20 (1990) 1
Institutions 30▿
- Case Western Reserve University 20
- TBA 16
- Mayo Clinic 12
- University Of Toronto 12
- Sri International 7
- Johann Wolfgang Goethe Universit£T 6
- Acadia Pharmaceuticals 5
- Amgen 4
- Burnham Center For Chemical Genomics 4
- University Of Bonn 4
- University Of Nebraska 4
- Schering-Plough Research Institute 3
- Friedrich-Schiller-University Jena 2
- Stanford University 2
- UniversitÉ 2
- Novo Industri 2
- Schering-Plough 1
- University Of North Texas 1
- Wroclaw Medical University 1
- University Of Chemistry And Technology Prague 1
- Uppsala University 1
- Albany Medical College 1
- The Scripps Research Institute 1
- University Of Washington 1
- The Scripps Research Institute Molecular Screening Center 1
- Astrazeneca 1
- University Of Manchester 1
- Korea Institute Of Science And Technology 1
- University Of Pennsylvania 1
- Universit£ 1
Affinity: 0.11 to 1.3E+5 nM▿
- Ki 95
- IC50 21
- EC50 3
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1