Release Notes for 2026-08-22: Number of new affinity data: 10190 Number of compounds (ligands) new to BindingDB: 7177 Number of Targets new to BindingDB: 7 New Targets: Dual specificity protein kinase CLK1 [129-484] (P49759[129-484]): 5 inhibitors Fibroblast growth factor receptor 4 [V550L] (P22455[V550L]): 80 inhibitors Histone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12 (unmapped): 32 inhibitors Histone-lysine N-methyltransferase EZH2 [Y641N]/Polycomb protein EED/Polycomb protein SUZ12 (unmapped): 32 inhibitors Receptor-interacting serine/threonine-protein kinase 2 and E3 ubiquitin-protein ligase XIAP (unmapped): 194 inhibitors Serine/threonine-protein kinase SIK1 [1-303] (P57059): 135 inhibitors Serine/threonine-protein kinase SIK3 [59-365] (Q9Y2K2[59-365]): 135 inhibitors Number of new Entries: 57 PubMed id or Patent id Title US12577217 15-PGDH inhibitor US12577230 2-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-1-yl)- acetamide derivatives as inhibitors of transforming growth factor-beta receptor I/ALK5 US12577235 Crystalline form of CXCR2 antagonist and application thereof US12577248 Substituted [1,2,4]triazolo[1,5-a]pyrazines as spleen tyrosine kinase inhibitors US12581252 Substituted pyrrolo[3,4-b]pyridines as PI3K-α inhibitors US12582650 IRAK4 kinase inhibitor and preparation method therefor US12582653 Method for treating idiopathic pulmonary fibrosis US12582654 Cyano-substituted pyridine and cyano-substituted pyrimidine compound and preparation method therefor and application thereof US12582655 Methods of treating disorders using CSFIR inhibitors US12583820 Broad spectrum antivirals against coronavirus US12583825 Benzo[h]quinazolin-4-amine and thieno[3,2-h]quinazolin-4-amine derivatives for the treatment of cancer US12583836 Sulphonamide compounds US12583841 Tetrahydropyrrolocyclic compound and application thereof US12583853 1H-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for the treatment of neoplastic and autoimmune diseases US12583855 RET selective inhibitor, preparation method therefor and use thereof US12583856 Inhibitors of protein kinase A US12590070 Adamantane derivatives as inhibitors of focal adhesion kinase US12590087 Inhibiting USP36 US12590092 Antiviral agents and uses thereof US12590118 Salt and crystal form of steroid derivative regulator US12594261 Use of heterocyclic derivatives with cardiomyocyte proliferation activity for treatment of heart diseases US12594277 Macrocyclic ULK1/2 inhibitors US12595236 Pyrimidine-2,4-diamine compound and preparation method and application thereof US12595267 Preparation method for amide compound and application thereof in field of medicine US20210101879 AMYLOID PROTEIN-SELECTIVE BACE INHIBITORS (ASBIs) FOR ALZHEIMER'S DISEASE US20260070924 INDAZOLE MACROCYCLES AND THEIR USE US20260070927 INDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE US20260076975 TPK AGONIST AND METHOD FOR USING SAME TO TREAT NEURODEGENERATIVE DISEASES US20260078095 NEUROTENSIN RECEPTOR LIGANDS US20260078114 COMPOUND USED AS INHIBITOR OF CDK4 KINASE AND USE THEREOF US20260078121 INHIBITORS OF ENL/AF9 YEATS AND FLT3 US20260078122 INDAZOLE COMPOUNDS AS PKMYT1 KINASE INHIBITORS US20260078123 PYRAZOLO[1,5-A]PYRIDINE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF US20260078129 JAK INHIBITOR AND PREPARATION METHOD THEREFOR US20260078130 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF US20260083851 POTENT ASGPR-BINDING HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF IMMUNOGLOBULINS AND OTHER PROTEINS US20260085034 N-(BENZHYDRYL)CYCLOALKYLCARBOXAMIDE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF US20260085046 Dual Function Compounds For NADPH Oxidase Inhibition And Histone Deacetylase Inhibition US20260085050 TRIPLE KINASE INHIBITORS US20260085053 BENZOFURAN DERIVATIVES AS SIK INHIBITORS AND THE USE THEREOF US20260085062 NOVEL COMPOUNDS AS CK2 INHIBITORS US20260085063 BENZAMIDE COMPOUNDS AND METHODS OF USE THEREOF US20260085069 PRODRUGS US20260085070 HETEROCYCLIC CBL-B INHIBITORS FOR THE TREATMENT OF CANCER US20260085073 PYRAZOLYLCARBOXAMIDE COMPOUNDS AND THEIR USE IN THERAPY US20260085076 CRYSTAL FORM OF AROMATIC HETEROCYCLIC COMPOUND, COMPOSITION THEREOF, PRODUCTION METHOD THEREOF AND USES THEREOF US20260091026 METHODS OF TREATING INFLAMMATORY DISEASES US20260092039 DUAL INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE US20260092055 Aromatic Acetylene Derivative, Preparation Method Therefor, And Pharmaceutical Use Thereof US20260092074 Annelated Pyridines as Steroidogenesis Inhibitors, Preparation Method and Use Thereof US20260098025 DIMERIC COMPOUNDS AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF US20260098038 NOVEL DERIVATIVES HAVING 2,3-DIHYDRO-1H-INDENE OR 2,3-DIHYDROBENZOFURAN MOIETY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME US20260098039 SOLID FORMS OF COMPOUND I OR SALTS THEREOF US20260098043 POLYCYCLIC COMPOUND AND USE THEREOF US20260098044 TRICYCLIC HETEROARYL COMPOUNDS AS INHIBITORS OF TYK2 AND/OR JAK1 US20260098060 MACROCYCLIC CFTR MODULATORS WO2020227365 Inhibiting USP19