Compile Data Set for Download or QSAR
Report error Found 429 Enz. Inhib. hit(s) with Target = 'CX3C chemokine receptor 1'
TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432452(CHEMBL2349310)
Affinity DataKi:  3.90nMAssay Description:Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432439(CHEMBL2349322)
Affinity DataKi:  4nMAssay Description:Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432471(CHEMBL2349316)
Affinity DataKi:  4.70nMAssay Description:Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCX3C chemokine receptor 1(Rat)
University of Texas System

US Patent
LigandPNGBDBM764618(N-[[1-(pyrrolidin-1-ylmethyl)cyclobutyl]methyl]- |...)
Affinity DataEC50:  5.80nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432466(CHEMBL2349180)
Affinity DataKi:  5.80nMAssay Description:Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764618(N-[[1-(pyrrolidin-1-ylmethyl)cyclobutyl]methyl]- |...)
Affinity DataEC50:  6nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764662(N-[[1-[(3-hydroxypiperidin-1-yl)methyl]cyclobutyl]...)
Affinity DataEC50:  6nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432467(CHEMBL2349179)
Affinity DataKi:  6.20nMAssay Description:Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCX3C chemokine receptor 1(Mouse)
University of Texas System

US Patent
LigandPNGBDBM764618(N-[[1-(pyrrolidin-1-ylmethyl)cyclobutyl]methyl]- |...)
Affinity DataEC50:  6.60nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Rat)
University of Texas System

US Patent
LigandPNGBDBM764646(N-[[1-[(4-methoxypiperidin-1-yl)methyl]cyclobutyl]...)
Affinity DataEC50:  6.60nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Rat)
University of Texas System

US Patent
LigandPNGBDBM764638(N-[[1-[(4-hydroxypiperidin-1-yl)methyl]cyclobutyl]...)
Affinity DataEC50:  7.40nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Rat)
University of Texas System

US Patent
LigandPNGBDBM764662(N-[[1-[(3-hydroxypiperidin-1-yl)methyl]cyclobutyl]...)
Affinity DataEC50:  7.40nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432450(CHEMBL2349312)
Affinity DataKi:  7.80nMAssay Description:Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432449(CHEMBL2349313)
Affinity DataKi:  8nMAssay Description:Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCX3C chemokine receptor 1(Mouse)
University of Texas System

US Patent
LigandPNGBDBM764652(N-[3-(3-methoxypiperidin-1-yl)-2,2-dimethylpropyl]...)
Affinity DataEC50:  8.10nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432429(CHEMBL2349332)
Affinity DataKi:  8.10nMAssay Description:Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764625(N-[[1-[(4-hydroxypiperidin-1-yl)methyl]cyclopentyl...)
Affinity DataEC50:  8.20nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432455(CHEMBL2349303)
Affinity DataKi:  8.30nMAssay Description:Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764602(N-[[1-(pyrrolidin-1-ylmethyl)cyclopentyl]methyl]- ...)
Affinity DataEC50:  8.40nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Rat)
University of Texas System

US Patent
LigandPNGBDBM764641(N-[[3-(pyrrolidin-1-ylmethyl)oxan-3-yl]methyl]-4,5...)
Affinity DataEC50:  8.40nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Rat)
University of Texas System

US Patent
LigandPNGBDBM764599(N-[[1-[(dimethylamino)methyl]cyclopentyl]methyl]- ...)
Affinity DataEC50:  8.5nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764650(N-[[1-[(4-methoxy-4-methylpiperidin-1-yl)methyl]cy...)
Affinity DataEC50:  8.60nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764638(N-[[1-[(4-hydroxypiperidin-1-yl)methyl]cyclobutyl]...)
Affinity DataEC50:  8.60nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Mouse)
University of Texas System

US Patent
LigandPNGBDBM764646(N-[[1-[(4-methoxypiperidin-1-yl)methyl]cyclobutyl]...)
Affinity DataEC50:  8.70nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764617(N-[[4-(pyrrolidin-1-ylmethyl)oxan-4-yl]methyl]-4,5...)
Affinity DataEC50:  8.80nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Mouse)
University of Texas System

US Patent
LigandPNGBDBM764656(N-[[1-[(3-hydroxy-3-methylpiperidin-1-yl)methyl] |...)
Affinity DataEC50:  9nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764611(N-[[1-(azetidin-1-ylmethyl)cyclopentyl]methyl]- | ...)
Affinity DataEC50:  9.10nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764629(N-[[3-hydroxy-1-(pyrrolidin-1-ylmethyl)cyclobutyl]...)
Affinity DataEC50:  9.10nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Rat)
University of Texas System

US Patent
LigandPNGBDBM764661(N-[[1-[(3-hydroxypyrrolidin-1-yl)methyl]cyclopenty...)
Affinity DataEC50:  9.10nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Mouse)
University of Texas System

US Patent
LigandPNGBDBM764609(N-[[1-(diethylaminomethyl)cyclopentyl]methyl]-4,5,...)
Affinity DataEC50:  9.10nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764633(N-[[1-(azetidin-1-ylmethyl)cyclobutyl]methyl]-4,5,...)
Affinity DataEC50:  9.10nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Rat)
University of Texas System

US Patent
LigandPNGBDBM764656(N-[[1-[(3-hydroxy-3-methylpiperidin-1-yl)methyl] |...)
Affinity DataEC50:  9.20nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Mouse)
University of Texas System

US Patent
LigandPNGBDBM764662(N-[[1-[(3-hydroxypiperidin-1-yl)methyl]cyclobutyl]...)
Affinity DataEC50:  9.20nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Rat)
University of Texas System

US Patent
LigandPNGBDBM764611(N-[[1-(azetidin-1-ylmethyl)cyclopentyl]methyl]- | ...)
Affinity DataEC50:  9.30nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764599(N-[[1-[(dimethylamino)methyl]cyclopentyl]methyl]- ...)
Affinity DataEC50:  9.30nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Rat)
University of Texas System

US Patent
LigandPNGBDBM764625(N-[[1-[(4-hydroxypiperidin-1-yl)methyl]cyclopentyl...)
Affinity DataEC50:  9.40nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764628(N-[[1-[(dimethylamino)methyl]-3-hydroxycyclobutyl]...)
Affinity DataEC50:  9.40nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Mouse)
University of Texas System

US Patent
LigandPNGBDBM764638(N-[[1-[(4-hydroxypiperidin-1-yl)methyl]cyclobutyl]...)
Affinity DataEC50:  9.40nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Rat)
University of Texas System

US Patent
LigandPNGBDBM764620(N-[[1-[(dimethylamino)methyl]cyclobutyl]methyl]- |...)
Affinity DataEC50:  9.5nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Mouse)
University of Texas System

US Patent
LigandPNGBDBM764636(N-[[3-(pyrrolidin-1-ylmethyl)oxolan-3-yl]methyl]- ...)
Affinity DataEC50:  9.60nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764641(N-[[3-(pyrrolidin-1-ylmethyl)oxan-3-yl]methyl]-4,5...)
Affinity DataEC50:  9.60nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Rat)
University of Texas System

US Patent
LigandPNGBDBM764660(N-[[1-[(3-hydroxypyrrolidin-1-yl)methyl]cyclopenty...)
Affinity DataEC50:  9.70nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764660(N-[[1-[(3-hydroxypyrrolidin-1-yl)methyl]cyclopenty...)
Affinity DataEC50:  9.80nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764635(N-[[3-[(dimethylamino)methyl]oxolan-3-yl]methyl]- ...)
Affinity DataEC50:  10nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Mouse)
University of Texas System

US Patent
LigandPNGBDBM764625(N-[[1-[(4-hydroxypiperidin-1-yl)methyl]cyclopentyl...)
Affinity DataEC50:  10nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764646(N-[[1-[(4-methoxypiperidin-1-yl)methyl]cyclobutyl]...)
Affinity DataEC50:  10nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432427(CHEMBL2349306)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764661(N-[[1-[(3-hydroxypyrrolidin-1-yl)methyl]cyclopenty...)
Affinity DataEC50:  10.2nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Rat)
University of Texas System

US Patent
LigandPNGBDBM764602(N-[[1-(pyrrolidin-1-ylmethyl)cyclopentyl]methyl]- ...)
Affinity DataEC50:  10.2nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM764627(N-[[1-[[2-hydroxyethyl(methyl)amino]methyl]cyclobu...)
Affinity DataEC50:  10.2nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent

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