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Report error Found 30 Enz. Inhib. hit(s) with Target = 'Calcium-activated potassium channel subunit beta'
TargetCalcium-activated potassium channel subunit beta-4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50514443(CHEMBL4563569)
Affinity DataKd:  1.10E+6nMAssay Description:Binding affinity to NT-495 fluorophore reagent labelled human BK beta4 (45 to 166 residues) incubated for 30 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCalcium-activated potassium channel subunit beta-4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50514447(CHEMBL4540900)
Affinity DataKd:  6.40E+5nMAssay Description:Binding affinity to NT-495 fluorophore reagent labelled human BK beta4 (45 to 166 residues) incubated for 30 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCalcium-activated potassium channel subunit beta-4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50514446(CHEMBL4524166)
Affinity DataKd:  5.50E+5nMAssay Description:Binding affinity to NT-495 fluorophore reagent labelled human BK beta4 (45 to 166 residues) incubated for 30 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCalcium-activated potassium channel subunit beta-4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50514444(CHEMBL4516172)
Affinity DataKd:  5.11E+5nMAssay Description:Binding affinity to NT-495 fluorophore reagent labelled human BK beta4 (45 to 166 residues) incubated for 30 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCalcium-activated potassium channel subunit beta-4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50514444(CHEMBL4516172)
Affinity DataKd:  9.75E+5nMAssay Description:Binding affinity to NT-495 fluorophore reagent labelled human BK beta4 Q124A mutant incubated for 30 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCalcium-activated potassium channel subunit beta-4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50514444(CHEMBL4516172)
Affinity DataKd:  7.82E+5nMAssay Description:Binding affinity to NT-495 fluorophore reagent labelled human BK beta4 E104K mutant incubated for 30 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCalcium-activated potassium channel subunit beta-4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50514445(CHEMBL4447233)
Affinity DataKd:  1.08E+8nMAssay Description:Binding affinity to NT-495 fluorophore reagent labelled human BK beta4 (45 to 166 residues) incubated for 30 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCalcium-activated potassium channel subunit beta-4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50514444(CHEMBL4516172)
Affinity DataIC50: 602nMAssay Description:Inhibition of human BK alpha/beta4 channel expressed in HEK293T cells assessed as inhibition of K+ outward current fraction at -80 mV holding potenti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCalcium-activated potassium channel subunit beta-1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of BK (unknown origin) by patch clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM86244(A-312110)
Affinity DataKi:  4.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
LigandPNGBDBM86250(NSC_43345 | CAS_60559-98-0 | P1075)
Affinity DataKi:  10.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
LigandPNGBDBM86250(NSC_43345 | CAS_60559-98-0 | P1075)
Affinity DataKi:  10.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
LigandPNGBDBM86247(CAS_3038059 | NSC_3038059 | BAY X 9228)
Affinity DataKi:  16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
LigandPNGBDBM86250(NSC_43345 | CAS_60559-98-0 | P1075)
Affinity DataKi:  20.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
LigandPNGBDBM86247(CAS_3038059 | NSC_3038059 | BAY X 9228)
Affinity DataKi:  41.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
LigandPNGBDBM86245(NSC_4826 | CAS_85371-64-8 | PINACIDIL)
Affinity DataKi:  104nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
LigandPNGBDBM86251(NSC_93504 | CAS_94535-50-9 | CROMAKALIM (-))
Affinity DataKi:  157nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
LigandPNGBDBM86245(NSC_4826 | CAS_85371-64-8 | PINACIDIL)
Affinity DataKi:  251nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
LigandPNGBDBM86249(ZD-6169 | ZD 6169)
Affinity DataKi:  451nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
LigandPNGBDBM86251(NSC_93504 | CAS_94535-50-9 | CROMAKALIM (-))
Affinity DataKi:  542nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
LigandPNGBDBM86249(ZD-6169 | ZD 6169)
Affinity DataKi:  630nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
LigandPNGBDBM86246(zm244085)
Affinity DataKi:  671nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
TargetCalcium-activated potassium channel subunit beta-1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50171290(SR 147778 | CHEMBL189676 | 5-(4-Bromo-phenyl)-1-(2...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
LigandPNGBDBM84745(DULOXETINE | LY-248686 | CAS_136434-34-9 | LY24868...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
LigandPNGBDBM86246(zm244085)
Affinity DataKi:  2.77E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
TargetCalcium-activated potassium channel subunit beta-1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM21280(N-(1,3,3-trimethylbicyclo(2.2.1)heptan-2-yl)-5-(4-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details
PubMed
LigandPNGBDBM86248(NSC_3019 | CAS_364-98-7 | diazoxide)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
LigandPNGBDBM86248(NSC_3019 | CAS_364-98-7 | diazoxide)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed