Compile Data Set for Download or QSAR
Report error Found 474 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor [L858R]'
TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195860(US9670213, Compound 005 8-(3-aminophenyl)-2-(4-met...)
Affinity DataIC50: 8.72E+4nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM494928(US10994015, Example 70 | 2-(2,6-dioxopiperidin-3-y...)
Affinity DataIC50: 3.00E+4nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM494929(US10994015, Example 71 | 2-(2,6-dioxopiperidin-3-y...)
Affinity DataIC50: 2.60E+4nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195885(US9670213, Compound 030 2-(4-aminophenylamino)-8-(...)
Affinity DataIC50: 2.38E+4nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195883(US9670213, Compound 028 2-(3-aminophenylamino)-8-(...)
Affinity DataIC50: 1.89E+4nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195081(US9670213, Compound 001 8-(4-aminophenyl)-2-(4-met...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195862(US9670213, Compound 007 N-(3-(2-(4-methoxyphenylam...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195863(US9670213, Compound 008 N-(4-(2-(4-methoxyphenylam...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM373719(US10246444, Example 55)
Affinity DataIC50: 1.00E+4nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM373720(US10246444, Example 58)
Affinity DataIC50: 1.00E+4nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM679665(US20240182487, Compound 64)
Affinity DataIC50: 1.00E+4nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM679667(US20240182487, Compound 66)
Affinity DataIC50: 1.00E+4nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM494931(US10994015, Example 73)
Affinity DataIC50: 9.80E+3nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195874(US9670213, Compound 019 N-(4-(2-(4-(4-methyl-1-pip...)
Affinity DataIC50: 6.38E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195865(US9670213, Compound 010 4-(dimethylamino)-N-(3-(2-...)
Affinity DataIC50: 6.08E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM373715(US10246444, Example 38)
Affinity DataIC50: 5.50E+3nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195867(US9670213, Compound 012 4-(dimethylamino)-N-(4-(7-...)
Affinity DataIC50: 5.34E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195859(US9670213, Compound 004 N-(4-(2-(4-methoxyphenylam...)
Affinity DataIC50: 4.88E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195858(US9670213, Compound 003 N-(4-(2-(4-morpholino-phen...)
Affinity DataIC50: 4.08E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM494876(US10994015, Example 10)
Affinity DataIC50: 3.50E+3nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM679668(US20240182487, Compound 67)
Affinity DataIC50: 1.72E+3nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195882(US9670213, Compound 027 N-(3-(8-(4-methoxyphenyl)-...)
Affinity DataIC50: 1.71E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195884(US9670213, Compound 029 N-(4-(8-(4-methoxyphenyl)-...)
Affinity DataIC50: 1.32E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM679662(US20240182487, Compound 38)
Affinity DataIC50: 1.14E+3nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM679697(US20240182487, Compound 98)
Affinity DataIC50: 1.11E+3nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM270539(2-(2-(5-chloro-2-(3-methoxy- 4-(4-methylpiperazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM270539(2-(2-(5-chloro-2-(3-methoxy- 4-(4-methylpiperazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM679670(US20240182487, Compound 69)
Affinity DataIC50: 1.00E+3nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM761638(2-(6-bromo-1-oxo-1,3-dihydro- 2H-pyrrolo[3,4-c]pyr...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM761640(2-(3-bromo-5-oxo-5,7-dihydro- 6H-pyrrolo[3,4-b]pyr...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM761641(2-(2-bromo-7-oxo-5,7-dihydro- 6H-pyrrolo[3,4-b]pyr...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM761642(2-(2-bromo-7-oxo-5,7-dihydro- 6H-pyrrolo[3,4-b]pyr...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM761649(2-(3-fluorophenyl)-2-(3-(6-(4- methylpiperazin-1-y...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM200758(US9670231, 1.60)
Affinity DataIC50: 949nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM765183(US12391671, Compound 068)
Affinity DataIC50: 756nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM373713(US10246444, Example 29)
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM373714(US10246444, Example 31)
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM373716(US10246444, Example 39)
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM373717(US10246444, Example 43)
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM373726(US10246444, Example 104)
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM373723(US10246444, Example 90)
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM373712(US10246444, Example 92)
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM373724(US10246444, Example 95)
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM270543(US10059688, Example 115 | US9783524, Example 115)
Affinity DataIC50: 547nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM270543(US10059688, Example 115 | US9783524, Example 115)
Affinity DataIC50: 547nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195857(US9670213, Compound 002 N-(4-(2-(4-methoxyphenylam...)
Affinity DataIC50: 546nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM200515(US9670231, 1.37)
Affinity DataIC50: 529nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM765150(US12391671, Compound 035)
Affinity DataIC50: 507nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM270540(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Affinity DataIC50: 500nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM270540(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Affinity DataIC50: 500nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

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