Compile Data Set for Download or QSAR
Report error Found 98 Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2 [575-869]'
LigandChemical structure of BindingDB Monomer ID 114904BDBM114904(US20260001898, Example A1)
Affinity DataKd:  0.00400nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701135BDBM701135(US20240343747, Example B39)
Affinity DataKd:  0.00600nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701134BDBM701134(US20240343747, Example B38)
Affinity DataKd:  0.00800nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701128BDBM701128(US20240343747, Example B29)
Affinity DataKd:  0.0100nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701136BDBM701136(US20240343747, Example B41)
Affinity DataKd:  0.0140nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701124BDBM701124(US20240343747, Example B11)
Affinity DataKd:  0.0160nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701132BDBM701132(US20240343747, Example B35)
Affinity DataKd:  0.0250nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701129BDBM701129(US20240343747, Example B32)
Affinity DataKd:  0.0250nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704883BDBM704883(US20240376093, Compound 3)
Affinity DataIC50: 0.0300nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701127BDBM701127(US20240343747, Example B24)
Affinity DataKd:  0.0300nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701122BDBM701122(US20240343747, Example B4)
Affinity DataKd:  0.0320nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704881BDBM704881(US20240376093, Compound 1)
Affinity DataIC50: 0.0400nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701120BDBM701120(US20240343747, Example B2)
Affinity DataKd:  0.0430nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701133BDBM701133(US20240343747, Example B37)
Affinity DataKd:  0.0440nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701131BDBM701131(US20240343747, Example B34)
Affinity DataKd:  0.0440nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704892BDBM704892(US20240376093, Compound 12)
Affinity DataIC50: 0.0500nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701130BDBM701130(US20240343747, Example B33)
Affinity DataKd:  0.0560nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704890BDBM704890(US20240376093, Compound 10)
Affinity DataIC50: 0.0600nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704882BDBM704882(US20240376093, Compound 2)
Affinity DataIC50: 0.0600nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701126BDBM701126(US20240343747, Example B22)
Affinity DataKd:  0.0630nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704889BDBM704889(US20240376093, Compound 9)
Affinity DataIC50: 0.0700nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704885BDBM704885(US20240376093, Compound 5)
Affinity DataIC50: 0.0700nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704884BDBM704884(US20240376093, Compound 4)
Affinity DataIC50: 0.0700nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701125BDBM701125(US20240343747, Example B19)
Affinity DataKd:  0.0750nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704895BDBM704895(US20240376093, Compound 15)
Affinity DataIC50: 0.0800nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704896BDBM704896(US20240376093, Compound 16)
Affinity DataIC50: 0.0800nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704887BDBM704887(US20240376093, Compound 7)
Affinity DataIC50: 0.0900nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704904BDBM704904(US20240376093, Compound 27)
Affinity DataIC50: 0.0900nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704898BDBM704898(US20240376093, Compound 18)
Affinity DataIC50: 0.0900nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701123BDBM701123(US20240343747, Example B5)
Affinity DataKd:  0.0950nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704891BDBM704891(US20240376093, Compound 11)
Affinity DataIC50: 0.110nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704906BDBM704906(US20240376093, Compound 29)
Affinity DataIC50: 0.110nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704893BDBM704893(US20240376093, Compound 13)
Affinity DataIC50: 0.120nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704899BDBM704899(US20240376093, Compound 19)
Affinity DataIC50: 0.120nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704903BDBM704903(US20240376093, Compound 23)
Affinity DataIC50: 0.130nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704901BDBM704901(US20240376093, Compound 21)
Affinity DataIC50: 0.130nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704902BDBM704902(US20240376093, Compound 22)
Affinity DataIC50: 0.140nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704888BDBM704888(US20240376093, Compound 8)
Affinity DataIC50: 0.150nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704905BDBM704905(US20240376093, Compound 28)
Affinity DataIC50: 0.170nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704886BDBM704886(US20240376093, Compound 6)
Affinity DataIC50: 0.180nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704900BDBM704900(US20240376093, Compound 20)
Affinity DataIC50: 0.190nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704894BDBM704894(US20240376093, Compound 14)
Affinity DataIC50: 0.25nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704897BDBM704897(US20240376093, Compound 17)
Affinity DataIC50: 0.290nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704910BDBM704910(US20240376093, Compound 33)
Affinity DataIC50: 0.300nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704909BDBM704909(US20240376093, Compound 32)
Affinity DataIC50: 0.310nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704908BDBM704908(US20240376093, Compound 31)
Affinity DataIC50: 0.340nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 701121BDBM701121(US20240343747, Example B3)
Affinity DataKd:  0.400nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704907BDBM704907(US20240376093, Compound 30)
Affinity DataIC50: 0.560nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704911BDBM704911(US20240376093, Compound 35)
Affinity DataIC50: 0.760nMAssay Description:0.5 nM TYK2 protein (His-TVMV-TYK2 JH2 (575-869)), 0.2 nM terbium-labeled His antibody, fluorescein-labeled kinase tracer at the relevant Kd value, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 500309BDBM500309(US11021475, Example 147)
Affinity DataEC50:  0.877nMAssay Description:The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

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