4OR2: Human class C G protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator

PDB ID: 4OR2Download
MMDB ID: 118496
PDB Deposition Date: 2014/2/10
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 4OR2: trimeric; determined by author and by software (PISA)
Molecular Components in 4OR2
Label Count Molecule
Proteins (3 molecules)
3
Soluble Cytochrome B562, Metabotropic Glutamate Receptor 1
(Gene symbol: GRM1)
Molecule annotation
Chemicals and Non-standard biopolymers (19 molecules)
1
3
4-fluoro-N-methyl-N-{4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl}benzamide4-fluoro-N-methyl-N-{4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl}benzamide
2
7
CHOLESTEROLCHOLESTEROL
3
1
OLEIC ACIDOLEIC ACID
4
4
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
5
4
PHOSPHATE IONPHOSPHATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303