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4J6I:
Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase beta isoform
PDB ID:
4J6I
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MMDB ID:
112999
PDB Deposition Date:
2013/2/11
Updated in MMDB:
2013/08
Experimental Method:
x-ray diffraction
Resolution:
2.9 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4J6I: monomeric; determined by author and by software (PISA)
Molecular Components in 4J6I
Label
Count
Molecule
Protein (1 molecule)
A
1
Phosphatidylinositol 4,5-bisphosphate 3-kinase Catalytic Subunit Gamma Isoform
(Gene symbol:
PIK3CG
)
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-methyl-1-(4-{2-[1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl]-4,5-dihydro[1]benzoxepino[5,4-d][1,3]thiazol-8-yl}-1H-pyrazol-1-yl)propan-2-ol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303