Abstract
Two new dihydroflavonols, phellodensin-A (1) and phellodensin-C (2); three new coumarins, phellodenol-A (3), phellodenol-B (4), and phellodenol-C (5); one new chlorophyll, phellophyll-a (6); and one new phenyllactate, (2R)-sodium 3-phenyllactate (7), in addition to 35 known compounds have been isolated from the leaves of Phellodendron amurense var. wilsonii. The structures of the new compounds were established based on 1D, 2D NMR and mass spectral analyses. The stereochemistry at the C-2, C-3, and C-2' ' positions of new dihydroflavonol 1 was determined by CD spectroscopy. The known compounds were identified by comparison with authentic samples. The antioxidant and antityrosinase activities were also described.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology
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Chlorophyll / chemistry
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Chlorophyll / isolation & purification*
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Chlorophyll / pharmacology
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Flavonols / chemistry
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Flavonols / isolation & purification*
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Flavonols / pharmacology
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Molecular Structure
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Monophenol Monooxygenase / antagonists & inhibitors*
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Nuclear Magnetic Resonance, Biomolecular
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Phellodendron / chemistry*
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Stereoisomerism
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Taiwan
Substances
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Antioxidants
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Coumarins
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Enzyme Inhibitors
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Flavonols
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phellodensin A
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phellodensin C
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Chlorophyll
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Monophenol Monooxygenase