Abstract
A simple and versatile method for preparation of (D)-Phe-Pro peptidomimetic bicyclic thiazolidine lactams is presented. These bicyclic lactams have chemical diversity alpha to the lactam carbonyl and, when linked to electrophilic arginines, provide potent thrombin inhibitors.
MeSH terms
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Antithrombins / chemical synthesis*
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Antithrombins / chemistry
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Antithrombins / pharmacology
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Bridged Bicyclo Compounds / chemical synthesis
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Bridged Bicyclo Compounds / chemistry
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Bridged Bicyclo Compounds / pharmacology
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Lactams / chemical synthesis
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Lactams / chemistry
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Lactams / pharmacology
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Structure-Activity Relationship
Substances
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Antithrombins
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Bridged Bicyclo Compounds
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Lactams