Abstract
A series of potent and selective factor Xa inhibitors was synthesized using various readily available amino acids as central templates. The most potent compound displays IC(50) of 3 nM.
MeSH terms
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Drug Design
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Factor Xa Inhibitors*
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Inhibitory Concentration 50
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Models, Molecular
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Serine Proteinase Inhibitors / chemical synthesis
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Serine Proteinase Inhibitors / chemistry
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Serine Proteinase Inhibitors / pharmacology*
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Structure-Activity Relationship
Substances
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Factor Xa Inhibitors
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Serine Proteinase Inhibitors