Isolation of 1-Methylherbipoline Salts of Halisulfate-1 and of Suvanine as Serine Protease Inhibitors from a Marine Sponge, Coscinoderma mathewsi

J Kimura; E Ishizuka; Y Nakao; WY Yoshida; PJ Scheuer; M Kelly-Borges

doi:10.1021/np970376z

Isolation of 1-Methylherbipoline Salts of Halisulfate-1 and of Suvanine as Serine Protease Inhibitors from a Marine Sponge, Coscinoderma mathewsi

J Nat Prod. 1998 Feb 27;61(2):248-50. doi: 10.1021/np970376z.

Authors

J Kimura¹, E Ishizuka, Y Nakao, WY Yoshida, PJ Scheuer, M Kelly-Borges

Affiliation

¹ Department of Chemistry, College of Science and Engineering, Aoyama Gakuin University, 6-16-1 Chitosedai, Setagaya, Tokyo, 157, Japan, Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii 96822-2275, and The Natural History Museum, Cromwell Road, London SW7 5BD, U.K.

PMID: 9548853
DOI: 10.1021/np970376z

Abstract

Bioassay-guided isolation of serine protease inhibitors from a marine sponge, Coscinoderma mathewsi, has yielded 1-methylherbipoline salts of halisulfate-1 and of suvanine. Structures of these compounds were identified by spectroscopic analyses and literature data. Antithrombin and antitrypsin activity was determined.