Abstract
An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Dose-Response Relationship, Drug
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Humans
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Male
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Molecular Structure
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Neurotensin / antagonists & inhibitors*
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Prostatic Neoplasms / drug therapy
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Pyrazoles / chemical synthesis*
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Pyrazoles / chemistry
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Quinolines / chemical synthesis*
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Quinolines / chemistry
Substances
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Pyrazoles
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Quinolines
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SR 48692
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Neurotensin