Inhibition of thermolysin with nitrone-bearing substrate analogs: a new type of thermolysin inhibitors

K J Lee; D H Kim

doi:10.1016/s0960-894x(98)00023-7

Inhibition of thermolysin with nitrone-bearing substrate analogs: a new type of thermolysin inhibitors

Bioorg Med Chem Lett. 1998 Feb 17;8(4):323-6. doi: 10.1016/s0960-894x(98)00023-7.

Authors

K J Lee¹, D H Kim

Affiliation

¹ Department of Chemistry, Pohang University of Science and Technology, Korea.

PMID: 9871678
DOI: 10.1016/s0960-894x(98)00023-7

Abstract

Nitrones are utilized as the active site zinc coordinating functionality in the design of inhibitors for thermolysin. This new type of thermolysin inhibitors are as potent as the existing inhibitors bearing a carboxylate or hydroxamate zinc ligating moiety.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Nitrogen Oxides / chemistry*
Protease Inhibitors / chemistry
Protease Inhibitors / pharmacology*
Structure-Activity Relationship
Thermolysin / antagonists & inhibitors*

Substances

Nitrogen Oxides
Protease Inhibitors
nitrones
Thermolysin